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Tatiana Segura


Professor of Biomedical Engineering

Professor Tatiana Segura received her BS degree in Bioengineering from the University of California Berkeley and her doctorate in Chemical Engineering from Northwestern University. Her graduate work in designing and understanding non-viral gene delivery from hydrogel scaffolds was supervised by Prof. Lonnie Shea. She pursued post-doctoral training at the Swiss Federal Institute of Technology, Lausanne under the guidance of Prof. Jeffrey Hubbell, where her focus was self-assembled polymer systems for gene and drug delivery. Professor Segura's Laboratory studies the use of materials for minimally invasive in situ tissue repair.   On this topic, she has published 113 peered reviewed publications to date. She has been recognized with the Outstanding Young Investigator Award from the American Society of Gene and Cell Therapy, the American Heart Association National Scientist Development Grant, and the CAREER award from National Science Foundation.  She was Elected to the College of Fellows at the American Institute for Medical and Biological Engineers (AIMBE) in 2017. She spent the first 11 years of her career at UCLA department of Chemical and Biomolecular Engineering and has recently relocated to Duke University, where she holds appointments in Biomedical Engineering, Neurology and Dermatology. 

Appointments and Affiliations

  • Professor of Biomedical Engineering
  • Professor in Neurology
  • Professor in Dermatology
  • Affiliate of the Duke Regeneration Center

Contact Information


  • Ph.D. Northwestern University, 2004

Research Interests

The design of biomaterials to promote endogenous repair and reducing inflammation through the design of the geometry of the material, and delivering genes, proteins and drugs.

Awards, Honors, and Distinctions

  • Fellow. American Institute for Medical and Biological Engineers. 2017
  • National Scientist Development Grant. American Heart Association. 2009
  • Outstanding Young Investigator Award. American Society of Gene and Cell Therapy. 2009
  • CAREER Award. National Science Foundation. 2008

Courses Taught

  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 771: Bioconjugation in drug biomaterials and drug delivery systems
  • BME 790: Advanced Topics for Graduate Students in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • EGR 393: Research Projects in Engineering
  • NEUROSCI 493: Research Independent Study 1
  • NEUROSCI 494: Research Independent Study 2
  • NEUROSCI 495: Research Independent Study 3

In the News

Representative Publications

  • Anderson, AR; Segura, T, Controlling Particle Fraction in Microporous Annealed Particle Scaffolds for 3D Cell Culture., Journal of Visualized Experiments : Jove no. 188 (2022) [10.3791/64554] [abs].
  • Anderson, AR; Nicklow, E; Segura, T, Particle fraction is a bioactive cue in granular scaffolds., Acta Biomaterialia, vol 150 (2022), pp. 111-127 [10.1016/j.actbio.2022.07.051] [abs].
  • Wilson, KL; Pérez, SCL; Naffaa, MM; Kelly, SH; Segura, T, Stoichiometric Post-Modification of Hydrogel Microparticles Dictates Neural Stem Cell Fate in Microporous Annealed Particle Scaffolds., Advanced Materials (Deerfield Beach, Fla.), vol 34 no. 33 (2022) [10.1002/adma.202201921] [abs].
  • Sideris, E; Kioulaphides, S; Wilson, K; Yu, A; Chen, J; Carmichael, ST; Segura, T, Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke., Advanced Therapeutics, vol 5 no. 8 (2022) [10.1002/adtp.202200048] [abs].
  • Kurt, E; Segura, T, Nucleic Acid Delivery from Granular Hydrogels., Advanced Healthcare Materials, vol 11 no. 3 (2022) [10.1002/adhm.202101867] [abs].

Affiliate Topics in Materials Research