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Shyni Varghese


Professor of Biomedical Engineering, Mechanical Engineering & Materials Science and Orthopaedics

Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.

A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:

  • Musculoskeletal tissue repair
  • Disease biophysics, and
  • Organ-on-a-chip technology

A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.

Appointments and Affiliations

  • Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
  • Professor of Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Duke Regeneration Center

Contact Information


  • Ph.D. National Chemical Laboratory (India), 2002

Research Interests

Musculoskeletal tissue repair, disease biophysics and organ-on-a-chip technology

Courses Taught

  • NEUROSCI 494: Research Independent Study 2
  • NEUROSCI 493: Research Independent Study 1
  • ME 592: Research Independent Study in Mechanical Engineering or Material Science
  • ME 591: Research Independent Study in Mechanical Engineering or Material Science
  • EGR 393: Research Projects in Engineering
  • BME 792: Continuation of Graduate Independent Study
  • BME 791: Graduate Independent Study
  • BME 590: Special Topics in Biomedical Engineering
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 394: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Cottrill, E; Pennington, Z; Sattah, N; Jing, C; Salven, D; Johnson, E; Downey, M; Varghese, S; Rocos, B; Richardson, W, Gene Therapy and Spinal Fusion: Systematic Review and Meta-analysis of the Available Data., World Neurosurg (2024) [10.1016/j.wneu.2024.03.174] [abs].
  • Price, MJ; Nguyen, AD; Haines, C; Baëta, CD; Byemerwa, J; Murkajee, D; Artham, S; Kumar, V; Lavau, C; Wardell, S; Varghese, S; Goodwin, CR, UDP-6-glucose dehydrogenase in hormonally responsive breast cancers., bioRxiv (2024) [10.1101/2024.03.20.585919] [abs].
  • Hainline, KM; Haddad, HF; Gilpin, A; Curvino, EJ; Varghese, S; Collier, JH, Active immunotherapy for C5a-mediated inflammation using adjuvant-free self-assembled peptide nanofibers., Acta Biomater (2024) [10.1016/j.actbio.2024.02.042] [abs].
  • Natesh, NR; Mogha, P; Chen, A; Antonia, SJ; Varghese, S, Differential roles of normal and lung cancer-associated fibroblasts in microvascular network formation., APL Bioeng, vol 8 no. 1 (2024) [10.1063/5.0188238] [abs].
  • Subramaniam, S; Akay, M; Anastasio, MA; Bailey, V; Boas, D; Bonato, P; Chilkoti, A; Cochran, JR; Colvin, V; Desai, TA; Duncan, JS; Epstein, FH; Fraley, S; Giachelli, C; Grande-Allen, KJ; Green, J; Guo, XE; Hilton, IB; Humphrey, JD; Johnson, CR; Karniadakis, G; King, MR; Kirsch, RF; Kumar, S; Laurencin, CT; Li, S; Lieber, RL; Lovell, N; Mali, P; Margulies, SS; Meaney, DF; Ogle, B; Palsson, B; A Peppas, N; Perreault, EJ; Rabbitt, R; Setton, LA; Shea, LD; Shroff, SG; Shung, K; Tolias, AS; van der Meulen, MCH; Varghese, S; Vunjak-Novakovic, G; White, JA; Winslow, R; Zhang, J; Zhang, K; Zukoski, C; Miller, MI, Grand Challenges at the Interface of Engineering and Medicine., IEEE Open J Eng Med Biol, vol 5 (2024), pp. 1-13 [10.1109/OJEMB.2024.3351717] [abs].

Affiliate Topics in Materials Research