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Shyni Varghese
Professor of Biomedical Engineering, Mechanical Engineering & Materials Science and Orthopaedics
Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.
A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:
- Musculoskeletal tissue repair
- Disease biophysics, and
- Organ-on-a-chip technology
A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.
Appointments and Affiliations
- Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
- Professor of Orthopaedic Surgery
- Professor in the Department of Mechanical Engineering and Materials Science
- Professor in the Department of Biomedical Engineering
- Affiliate of the Duke Regeneration Center
Contact Information
- Email Address: shyni.varghese@duke.edu
- Websites:
Education
- Ph.D. National Chemical Laboratory (India), 2002
Research Interests
Musculoskeletal tissue repair, disease biophysics and organ-on-a-chip technology
Courses Taught
- NEUROSCI 494: Research Independent Study 2
- NEUROSCI 493: Research Independent Study 1
- ME 592: Research Independent Study in Mechanical Engineering or Material Science
- ME 591: Research Independent Study in Mechanical Engineering or Material Science
- EGR 393: Research Projects in Engineering
- BME 792: Continuation of Graduate Independent Study
- BME 791: Graduate Independent Study
- BME 590: Special Topics in Biomedical Engineering
- BME 494: Projects in Biomedical Engineering (GE)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 394: Projects in Biomedical Engineering (GE)
In the News
- Injecting Hope (Nov 12, 2024 | Duke Today)
- Protecting Bones from Cancer Treatment (Dec 5, 2023 | School of Medicine)
- Organ-on-a-chip: Better Health Care Through Superior Drug Testing (Nov 24, 2021 | Duke Science & Technology)
- Soft Robotic Dragonfly Signals Environmental Disruptions (Mar 25, 2021 | Pratt School of Engineering)
- A Crystal Ball for the Decade Ahead (Jan 9, 2020)
- Engineering a Better Bandage to Promote Faster Healing (Dec 13, 2019 | Pratt School of Engineering)
- Big Ideas on a Small Chip Surface (Nov 1, 2019 | Pratt School of Engineering)
- Researchers ID Pharmaceutical Target That Reverses Osteoporosis in Mice (Aug 22, 2019 | Pratt School of Engineering)
- Shyni Varghese: Making Miniature Models of Muscles, Bones and Tumors (Nov 18, 2016 | Pratt School of Engineering)
Representative Publications
- Gonzales, G; Hoque, J; Kaeo, C; Zauscher, S; Varghese, S, Grafting of cationic molecules to hyaluronic acid improves adsorption and cartilage lubrication., Biomater Sci, vol 12 no. 18 (2024), pp. 4747-4758 [10.1039/d4bm00532e] [abs].
- Cottrill, E; Pennington, Z; Sattah, N; Jing, C; Salven, D; Johnson, E; Downey, M; Varghese, S; Rocos, B; Richardson, W, Gene Therapy and Spinal Fusion: Systematic Review and Meta-Analysis of the Available Data., World Neurosurg, vol 186 (2024), pp. 219-234.e4 [10.1016/j.wneu.2024.03.174] [abs].
- Gonzales, G; Hoque, J; Gilpin, A; Maity, B; Zauscher, S; Varghese, S, Branched poly-l-lysine for cartilage penetrating carriers., Bioeng Transl Med, vol 9 no. 3 (2024) [10.1002/btm2.10612] [abs].
- Hainline, KM; Haddad, HF; Gilpin, A; Curvino, EJ; Varghese, S; Collier, JH, Active immunotherapy for C5a-mediated inflammation using adjuvant-free self-assembled peptide nanofibers., Acta Biomater, vol 179 (2024), pp. 83-94 [10.1016/j.actbio.2024.02.042] [abs].
- Price, MJ; Nguyen, AD; Haines, C; Baëta, CD; Byemerwa, J; Murkajee, D; Artham, S; Kumar, V; Lavau, C; Wardell, S; Varghese, S; Goodwin, CR, UDP-6-glucose dehydrogenase in hormonally responsive breast cancers., bioRxiv (2024) [10.1101/2024.03.20.585919] [abs].