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Shyni Varghese


Professor of Biomedical Engineering, Mechanical Engineering & Materials Science and Orthopaedics

Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.

A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:

  • Musculoskeletal tissue repair
  • Disease biophysics, and
  • Organ-on-a-chip technology

A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.

Appointments and Affiliations

  • Professor of Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Ph.D. National Chemical Laboratory (India), 2002

Research Interests

Musculoskeletal tissue repair, disease biophysics and organ-on-a-chip technology

Courses Taught

  • BME 290L: Intermediate Topics with Lab (GE)
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 590: Special Topics in Biomedical Engineering
  • BME 791: Graduate Independent Study
  • ME 221L: Structure and Properties of Solids
  • ME 555: Advanced Topics in Mechanical Engineering
  • ME 591: Research Independent Study in Mechanical Engineering or Material Science

In the News

Representative Publications

  • Hoque, J; Shih, Y-RV; Zeng, Y; Newman, H; Sangaj, N; Arjunji, N; Varghese, S, Bone targeting nanocarrier-assisted delivery of adenosine to combat osteoporotic bone loss., Biomaterials, vol 273 (2021) [10.1016/j.biomaterials.2021.120819] [abs].
  • Nayak, P; Colas, A; Mercola, M; Varghese, S; Subramaniam, S, Temporal mechanisms of myogenic specification in human induced pluripotent stem cells., Science Advances, vol 7 no. 12 (2021) [10.1126/sciadv.abf7412] [abs].
  • Andress, B; Kim, JH; Cutcliffe, HC; Amendola, A; Goode, AP; Varghese, S; DeFrate, LE; McNulty, AL, Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding., J Orthop Res (2020) [10.1002/jor.24954] [abs].
  • Moreno, AM; Fu, X; Zhu, J; Katrekar, D; Shih, Y-RV; Marlett, J; Cabotaje, J; Tat, J; Naughton, J; Lisowski, L; Varghese, S; Zhang, K; Mali, P, In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation., Molecular Therapy : the Journal of the American Society of Gene Therapy, vol 28 no. 8 (2020) [10.1016/j.ymthe.2020.06.027] [abs].
  • Zeng, Y; Shih, Y-RV; Baht, GS; Varghese, S, In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing., Adv Mater, vol 32 no. 8 (2020) [10.1002/adma.201906022] [abs].

Affiliate Topics in Materials Research