You are here
Ashutosh Chilkoti
Alan L. Kaganov Distinguished Professor of Biomedical Engineering
Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering at Duke University.
My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technologies that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic biosensors, low-cost clinical diagnostics, and drug delivery.
Appointments and Affiliations
- Alan L. Kaganov Distinguished Professor of Biomedical Engineering
- Professor of Biomedical Engineering
- Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science
- Research Professor of Global Health
- Professor in the Department of Chemistry
- Core Faculty in Innovation & Entrepreneurship
- Member of the Duke Cancer Institute
Contact Information
- Office Location: 3381 CIEMAS, Durham, NC 27708
- Office Phone: +1 919 660 5373
- Email Address: chilkoti@duke.edu
- Websites:
Education
- Ph.D. University of Washington, 1991
Research Interests
Focused on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, biomaterials, and targeted drug delivery.
Awards, Honors, and Distinctions
- Distinguished Alumnus Award. Indian Institute of Technology Delhi, India. 2015
- Fellow (NAI). National Academy of Inventors. 2014
- Pritzker Distinguished Lecture Award. Biomedical Engineering Society. 2013
- Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011
- Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011
- Humboldt Senior Researcher Award. Alexander Von Humboldt Foundation. 2010
- Stansell Family Distinguished Research Award. Duke University, Pratt School of Engineering. 2008
- Fellow. American Institute for Medical and Biological Engineering. 1996
Courses Taught
- MSEG 591: Independent Study
- EGR 393: Research Projects in Engineering
- EGR 391: Projects in Engineering
- BME 792: Continuation of Graduate Independent Study
- BME 791: Graduate Independent Study
- BME 789: Internship in Biomedical Engineering
- BME 570L: Introduction to Biomolecular Engineering (GE, BB, MC)
- BME 494: Projects in Biomedical Engineering (GE)
- BME 493: Projects in Biomedical Engineering (GE)
- BME 394: Projects in Biomedical Engineering (GE)
In the News
- Hard-Earned Lessons from Spinning Out a Startup Company from a University (Oct 25, 2024 | Pratt School of Engineering)
- Low-Cost, Gravity-Powered Approach for Biomedical Devices (Jul 12, 2023 | Pratt School of Engineering)
- Inside the Journey of a Duke Biotech Start-Up (Mar 10, 2023 | Duke Translation & Commercialization)
- Synthetic Compartments Stop Pathogens from Sharing Antibiotic Resistance Genes (Feb 9, 2023 | Pratt School of Engineering)
- Implant Obliterates Pancreatic Cancer in Mice (Nov 3, 2022 | Pratt School of Engineering)
- Rapid Test Identifies Antibody Effectiveness Against COVID-19 Variants (Dec 6, 2021 | Pratt School of Engineering)
- Type 2 Diabetes Drugs Work Better in Tethered Combination Therapy (Aug 26, 2020 | Pratt School of Engineering)
- Duke Engineers Adapt Rapid Testing Platform to See If It Can Catch COVID-19 (Apr 28, 2020 | Pratt School of Engineering)
- Heat and Light Create Never-Before-Seen Biocompatible Microparticles (Mar 12, 2020 | Pratt School of Engineering)
- Seven From Duke Named Fellows of American Association for the Advancement of Science (Nov 26, 2019)
- How Stabilizing Disordered Proteins May Lead to the Next Generation of Medical Applications (Oct 29, 2019 | Pratt School of Engineering)
- Cancer Therapy Using Genetic Targeting and Gel Delivery Shows Promise (Sep 16, 2019 | Pratt School of Engineering)
- A Year of Real-World Biomedical Engineering Design (Oct 30, 2018 | Pratt School of Engineering)
- Biomaterials with "Frankenstein Proteins" Help Heal Tissue (Oct 15, 2018 | Pratt School of Engineering)
- Inkjet-Printed Tool Enables Sensitive Diagnostic Testing in Point-of-Care Settings (Aug 8, 2017 | Pratt School of Engineering)
- Portable diagnostic tool detects disease in 15 minutes (Aug 8, 2017 | The Engineer)
- Injectable Solution May Provide Weeks of Glucose Control (Jun 5, 2017 | Pratt School of Engineering)
- Engineered "Spaghetti-Ball" Proteins Provide Biomedical Insights (Jan 30, 2017 | Pratt School of Engineering)
- Duke buys back PhaseBio's anticancer option (Mar 29, 2016 | WRAL Tech Wire)
- Traveling Salesman Uncorks Synthetic Biology Bottleneck (Jan 5, 2016 | Pratt School of Engineering)
- Protein Structures Assemble and Disassemble On Command (Sep 21, 2015 | Pratt School of Engineering)
- Packaging cancer drug into nanoparticles doubles tumor destroying efficacy (Aug 5, 2015 | AZoNano)
- Chilkoti Named Chair of Duke BME (Aug 8, 2014 | Pratt School of Engineering)
Representative Publications
- Joh, DY; Hucknall, AM; Wei, Q; Mason, KA; Lund, ML; Fontes, CM; Hill, RT; Blair, R; Zimmers, Z; Achar, RK; Tseng, D; Gordan, R; Freemark, M; Ozcan, A; Chilkoti, A, Inkjet-printed point-of-care immunoassay on a nanoscale polymer brush enables subpicomolar detection of analytes in blood., Proc Natl Acad Sci U S A, vol 114 no. 34 (2017), pp. E7054-E7062 [10.1073/pnas.1703200114] [abs].
- Luginbuhl, KM; Schaal, JL; Umstead, B; Mastria, EM; Li, X; Banskota, S; Arnold, S; Feinglos, M; D'Alessio, D; Chilkoti, A, One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer., Nat Biomed Eng, vol 1 (2017) [10.1038/s41551-017-0078] [abs].
- Tang, NC; Chilkoti, A, Combinatorial codon scrambling enables scalable gene synthesis and amplification of repetitive proteins., Nature materials, vol 15 no. 4 (2016), pp. 419-424 [10.1038/nmat4521] [abs].
- Qi, Y; Simakova, A; Ganson, NJ; Li, X; Luginbuhl, KM; Özer, I; Liu, W; Hershfield, MS; Matyjaszewski, K; Chilkoti, A, A brush-polymer conjugate of exendin-4 reduces blood glucose for up to five days and eliminates poly(ethylene glycol) antigenicity., Nat Biomed Eng, vol 1 (2016) [10.1038/s41551-016-0002] [abs].
- Quiroz, FG; Chilkoti, A, Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers., Nature materials, vol 14 no. 11 (2015), pp. 1164-1171 [10.1038/nmat4418] [abs].
- Bhattacharyya, J; Bellucci, JJ; Weitzhandler, I; McDaniel, JR; Spasojevic, I; Li, X; Lin, C-C; Chi, J-TA; Chilkoti, A, A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models., Nat Commun, vol 6 (2015) [10.1038/ncomms8939] [abs].
- Amiram, M; Quiroz, FG; Callahan, DJ; Chilkoti, A, A highly parallel method for synthesizing DNA repeats enables the discovery of 'smart' protein polymers., Nat Mater, vol 10 no. 2 (2011), pp. 141-148 [10.1038/nmat2942] [abs].
- MacKay, JA; Chen, M; McDaniel, JR; Liu, W; Simnick, AJ; Chilkoti, A, Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection, NATURE MATERIALS, vol 8 no. 12 (2009), pp. 993-999 [10.1038/NMAT2569] [abs].
- Meyer, DE; Chilkoti, A, Purification of recombinant proteins by fusion with thermally-responsive polypeptides., Nat Biotechnol, vol 17 no. 11 (1999), pp. 1112-1115 [10.1038/15100] [abs].